Article
Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity.
Acta neuropathologica - 1 Feb 2006
Wilhelmus Micha M M, Boelens Wilbert C, Otte-Höller Irene, Kamps Bram, Kusters Benno, Maat-Schieman Marion L C, de Waal Robert M W, Verbeek Marcel M
Abstract excerpt
Alzheimer's disease (AD) is characterized by pathological lesions, such as senile plaques (SPs) and cerebral amyloid angiopathy (CAA), both predominantly consisting of a proteolytic cleavage product of the amyloid-beta precursor protein (APP), the amyloid-beta peptide (Abeta). CAA is also the major pathological lesion in hereditary cerebral hemorrhage with amyloidosis of the Dutch type (HCHWA-D), caused by a...
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