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Article

The influence of 5-HTTLPR genotype on the association between the plasma concentration and therapeutic effect of paroxetine in patients with major depressive disorder.

PloS one - 1 Jan 2014

Tomita Tetsu, Yasui-Furukori Norio, Nakagami Taku, Tsuchimine Shoko, Ishioka Masamichi, Kaneda Ayako, Sugawara Norio, Kaneko Sunao

Abstract excerpt

INTRODUCTION: The efficacy of treatment with selective serotonin reuptake inhibitors in patients with major depressive disorder (MDD) can differ depending on the patient's serotonin transporter-linked polymorphic region (5-HTTLPR) genotype, and the effects of varying plasma concentrations of drugs can also vary. We investigated the association between the paroxetine plasma concentration and clinical response in...

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Source

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Identifiers

PMID: 24858363
DOI: 10.1371/journal.pone.0098099
PMCID: PMC4032230

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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