Article
DiSSiMiL: Diverse Small Size Mini-Libraries applied to simple and rapid epitope mapping of a monoclonal antibody.
The journal of peptide research : official journal of the American Peptide Society - 1 Jan 2001
Burgess K, Han I, Zhang A, Zheng W H, Shanmugam K, Featherstone M S, Saragovi H U
Abstract excerpt
Methods for screening protein-protein interactions are useful in protein science and for the generation of drug leads. We set out to develop a simplified assay to rapidly test protein-protein interactions, with a library of 400 pentapeptides comprising the 20 natural amino acids at two variable positions followed by three glycines (NH2-X1X2GGG). The library was used to identify the epitope of monoclonal antibody...
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