A general approach for identifying protein epitopes targeted by antibody repertoires using whole proteomes

Abstract excerpt

Antibodies are essential to functional immunity, yet the epitopes targeted by antibody repertoires remain largely uncharacterized. To aid in characterization, we developed a generalizable strategy to identify antibody-binding epitopes within individual proteins and entire proteomes. Specifically, we selected antibody-binding peptides for 273 distinct sera out of a random library and identified the peptides using n...

Topics

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• Cytomegalovirus and herpesvirus research
• Glycosylation and Glycoproteins Research
• HIV Research and Treatment
• Immune Cell Function and Interaction
• Immunotherapy and Immune Responses
• Monoclonal and Polyclonal Antibodies Research
• T-cell and B-cell Immunology
• vaccines and immunoinformatics approaches

Identifiers and source

Literature Corpus work

ef9ec0d1-f998-5c81-8797-b7cd8751c41e

DOI

10.1101/641787