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Article

Lysosomes Signal through Epigenome to Regulate Longevity across Generations

2025-05-23

Abstract excerpt

Epigenome is sensitive to metabolic inputs and crucial for aging. Lysosomes emerge as a signaling hub to sense metabolic cues and regulate longevity. We unveil that lysosomal metabolic pathways signal through the epigenome to regulate transgenerational longevity in Caenorhabditis elegans . We discovered that the induction of lysosomal lipid signaling and lysosomal AMP-activated protein kinase (AMPK), or the reduc...

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Identifiers and source

Literature Corpus work
61e588da-fedf-58eb-a359-3701733b54f8
DOI
10.1101/2025.05.21.652954
Open publication

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Lysosomes Signal through Epigenome to Regulate Longevity across GenerationsDOI 10.1101/2025.05.21.652954
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