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Article

Insulin-degrading enzyme (IDE) as a modulator of microglial phenotypes in the context of Alzheimer's disease and brain aging.

Journal of neuroinflammation - 11 Oct 2023

Corraliza-Gomez Miriam, Bermejo Teresa, Lilue Jingtao, Rodriguez-Iglesias Noelia, Valero Jorge, Cozar-Castellano Irene, Arranz Eduardo, Sanchez Diego, Ganfornina Maria Dolores

Abstract excerpt

The insulin-degrading enzyme (IDE) is an evolutionarily conserved zinc-dependent metallopeptidase highly expressed in the brain, where its specific functions remain poorly understood. Besides insulin, IDE is able to cleave many substrates in vitro, including amyloid beta peptides, making this enzyme a candidate pathophysiological link between Alzheimer's disease (AD) and type 2 diabetes (T2D). These antecedents...

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Identifiers

PMID: 37817156
DOI: 10.1186/s12974-023-02914-7
PMCID: PMC10566021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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