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Article

Association of polymorphisms in the insulin-degrading enzyme gene with type 2 diabetes in the Korean population.

Diabetes research and clinical practice - 1 Feb 2008

Kwak S H, Cho Y M, Moon M K, Kim J H, Park B L, Cheong H S, Shin H D, Jang H C, Kim S Y, Lee H K, Park K S

Abstract excerpt

Insulin-degrading enzyme (IDE) is a metalloproteinase which degrades insulin and terminates its action. Homologous deletion of IDE gene resulted in hyperinsulinemia and glucose intolerance in a rat model of type 2 diabetes mellitus. Several genetic association studies examined IDE as a susceptibility gene for type 2 diabetes in European descents. Here we investigated the genetic association of IDE polymorphisms...

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Source

Identifiers

PMID: 17913278
DOI: 10.1016/j.diabres.2007.08.017

Genes

IDE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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