Insulin-Degrading Enzyme in the Fight against Alzheimer's Disease.

Abstract excerpt

After decades of research and clinical trials there is still no cure for Alzheimer's disease (AD). While impaired clearance of amyloid beta (Aβ) peptides is considered as one of the major causes of AD, it was recently complemented by a potential role of other toxic amyloidogenic species. Insulin-degrading enzyme (IDE) is the proteolytic culprit of various β-forming peptides, both extracellular and intracellular....

Topics

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• Allosteric Regulation
• Alzheimer Disease
• Amyloid
• IDE gene
• Insulysin
• Mutation