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Article

GliA in Aspergillus fumigatus is required for its tolerance to gliotoxin and affects the amount of extracellular and intracellular gliotoxin.

Medical mycology - 1 Jul 2014

Wang Dan-Ni, Toyotome Takahito, Muraosa Yasunori, Watanabe Akira, Wuren Tuya, Bunsupa Somnuk, Aoyagi Kaori, Yamazaki Mami, Takino Masahiko, Kamei Katsuhiko

Abstract excerpt

Gliotoxin is an important virulence factor of Aspergillus fumigatus. Although GliA putatively belongs to the major facilitator superfamily in the gliotoxin biosynthesis cluster, its roles remain unclear. To determine the function of GliA, we disrupted gliA in A. fumigatus. gliA disruption increased the susceptibility of A. fumigatus to gliotoxin. The gliT and gliA double-disrupted mutant had even higher...

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PMID: 24847038
DOI: 10.1093/mmy/myu007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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