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Article

Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.

Eukaryotic cell - 1 Jun 2006

Cramer Robert A, Gamcsik Michael P, Brooking Rhea M, Najvar Laura K, Kirkpatrick William R, Patterson Thomas F, Balibar Carl J, Graybill John R, Perfect John R, Abraham Soman N, Steinbach William J

Abstract excerpt

The fungal secondary metabolite gliotoxin produced by Aspergillus fumigatus has been hypothesized to be important in the development of invasive aspergillosis. In this study, we addressed this hypothesis by disrupting a nonribosomal peptide synthetase (NRPS) (encoded by gliP) predicted to be involved in gliotoxin production. Mutants with a disrupted gliP locus failed to produce gliotoxin, which confirmed the role...

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Identifiers

PMID: 16757745
DOI: 10.1128/EC.00049-06
PMCID: PMC1489275

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production.PMID 16757745Read ↗

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