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Article

The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus.

Chemistry & biology - 22 Apr 2011

Davis Carol, Carberry Stephen, Schrettl Markus, Singh Ishwar, Stephens John C, Barry Sarah M, Kavanagh Kevin, Challis Gregory L, Brougham Dermot, Doyle Sean

Abstract excerpt

Gliotoxin, a redox-active metabolite, is produced by the opportunistic fungal pathogen Aspergillus fumigatus, and its biosynthesis is directed by the gli gene cluster. Knowledge of the biosynthetic pathway to gliotoxin, which contains a disulfide bridge of unknown origin, is limited, although L-Phe and L-Ser are known biosynthetic precursors. Deletion of gliG from the gli cluster, herein functionally confirmed as...

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PMID: 21513890
DOI: 10.1016/j.chembiol.2010.12.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of glutathione S-transferase GliG in gliotoxin biosynthesis in Aspergillus fumigatus.PMID 21513890Read ↗

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