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Gliotoxin, a known virulence factor in the major human pathogen <i>Aspergillus fumigatus</i> , is also biosynthesized by the non-pathogenic relative <i>A. fischeri</i>

2019-12-08

Abstract excerpt

<h4>ABSTRACT</h4> Aspergillus fumigatus is a major opportunistic human pathogen. Multiple traits contribute to A. fumigatus pathogenicity, including its ability to produce specific secondary metabolites, such as gliotoxin. Gliotoxin is known to inhibit the host immune response, and genetic mutants that inactivate gliotoxin biosynthesis (or secondary metabolism in general) attenuate A. fumigatus virulence. The g...

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Literature Corpus work
09416e0b-80fb-5ada-8a8f-d78df0976a56
DOI
10.1101/868745
Open publication

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