Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In vitro study on aspects of molecular mechanisms underlying invasive aspergillosis caused by gliotoxin and fumagillin, alone and in combination

2 Sept 2020

Abstract excerpt

Abstract Gliotoxin (GT) and fumagillin (FUM) are mycotoxins most abundantly produced byAspergillus fumigatusduring the early stages of infection to cause invasive aspergillosis (IA).Therefore, we hypothesized that GT and FUM could be the possible source of virulence factors, which we put to test adopting in vitro monoculture and the novel integrated multiple organ co-culture (IdMOC) of A549 and L132 cell. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antifungal resistance and susceptibility
Share to Peptidase Inhibition and Analysis
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32879392
DOI: 10.1038/s41598-020-71367-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In vitro study on aspects of molecular mechanisms underlying invasive aspergillosis caused by gliotoxin and fumagillin, alone and in combinationPMID 32879392Read ↗

Gliotoxin, a known virulence factor in the major human pathogen <i>Aspergillus fumigatus</i> , is also biosynthesized by the non-pathogenic relative <i>A. fischeri</i>Semantic proximity Read ↗

<i>Aspergillus</i>mycotoxins and their effect on the hostSemantic proximity Read ↗

Fumagillin, a Mycotoxin of Aspergillus fumigatus: Biosynthesis, Biological Activities, Detection, and ApplicationsSemantic proximity Read ↗

Regulation of gliotoxin biosynthesis and protection in Aspergillus speciesSemantic proximity Read ↗

Host immune status-specific production of gliotoxin and bis-methyl-gliotoxin during invasive aspergillosis in miceSemantic proximity Read ↗

Biosynthetic gene clusters, secondary metabolite profiles, and cards of virulence in the closest nonpathogenic relatives of <i>Aspergillus fumigatus</i>Semantic proximity Read ↗

What do we know about the role of gliotoxin in the pathobiology of<i>Aspergillus fumigatus?</i>Semantic proximity Read ↗

GliZ, a Transcriptional Regulator of Gliotoxin Biosynthesis, Contributes to<i>Aspergillus fumigatus</i>VirulenceSemantic proximity Read ↗

Gliotoxin, a Known Virulence Factor in the Major Human Pathogen Aspergillus fumigatus, Is Also Biosynthesized by Its Nonpathogenic Relative Aspergillus fischeriSemantic proximity Read ↗

The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulenceSemantic proximity Read ↗

Regulation of gliotoxin biosynthesis and protection in <i>Aspergillus</i> speciesSemantic proximity Read ↗

Elucidating the combined toxicity of aflatoxin B1 and fumonisin B1 on HepG2 cells based on respirometry and transcriptome analysesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.