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Article

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus.

Open biology - 1 Feb 2017

Dolan Stephen K, Bock Tobias, Hering Vanessa, Owens Rebecca A, Jones Gary W, Blankenfeldt Wulf, Doyle Sean

Abstract excerpt

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that mediates its toxic effects via redox cycling and is produced by the opportunistic fungal pathogen Aspergillus fumigatus Self-resistance against gliotoxin is effected by the gliotoxin oxidase GliT, and attenuation of gliotoxin biosynthesis is catalysed by gliotoxin S-methyltransferase GtmA. Here we describe the X-ray...

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Identifiers

PMID: 28179499
DOI: 10.1098/rsob.160292
PMCID: PMC5356443

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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