Article
Expressions of tight junction proteins Occludin and Claudin-1 are under the circadian control in the mouse large intestine: implications in intestinal permeability and susceptibility to colitis.
PloS one - 1 Jan 2014
Kyoko Oh-oka, Kono Hiroshi, Ishimaru Kayoko, Miyake Kunio, Kubota Takeo, Ogawa Hideoki, Okumura Ko, Shibata Shigenobu, Nakao Atsuhito
Abstract excerpt
BACKGROUND & AIMS: The circadian clock drives daily rhythms in behavior and physiology. A recent study suggests that intestinal permeability is also under control of the circadian clock. However, the precise mechanisms remain largely unknown. Because intestinal permeability depends on tight junction (TJ) that regulates the epithelial paracellular pathway, this study investigated whether the circadian clock...
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