Article

Continuous Light-Induced Circadian Rhythm Disruption Impairs Intestinal Barrier Integrity in Male C57BL/6 Mice Through Gut Microbiota Dysbiosis and the Apoptosis-Inflammation-Oxidative Stress Cascade

2025-11-13

Abstract excerpt

<h4>Background</h4> Circadian rhythm disruption (CRD) is a risk factor for irritable bowel syndrome (IBS), but the mechanism linking CRD to intestinal barrier dysfunction remains unclear. This preclinical study aimed to clarify whether CRD impairs intestinal barrier integrity via gut microbiota dysbiosis and the “apoptosis-inflammation-oxidative stress” cascade. <h4>Methods</h4> Twenty-four male C57BL/6 mice wer...

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Literature Corpus work: 17df78f3-eb81-5a51-b978-ebf2380da0cc
DOI: 10.1101/2025.11.11.687914

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Continuous Light-Induced Circadian Rhythm Disruption Impairs Intestinal Barrier Integrity in Male C57BL/6 Mice Through Gut Microbiota Dysbiosis and the Apoptosis-Inflammation-Oxidative Stress CascadeDOI 10.1101/2025.11.11.687914Read

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