Article
Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2017
Pagel René, Bär Florian, Schröder Torsten, Sünderhauf Annika, Künstner Axel, Ibrahim Saleh M, Autenrieth Stella E, Kalies Kathrin, König Peter, Tsang Anthony H, Bettenworth Dominik, Divanovic Senad, Lehnert Hendrik, Fellermann Klaus, Oster Henrik, Derer Stefanie, Sina Christian
Abstract excerpt
Endogenous circadian clocks regulate 24-h rhythms of physiology and behavior. Circadian rhythm disruption (CRD) is suggested as a risk factor for inflammatory bowel disease. However, the underlying molecular mechanisms remain unknown. Intestinal biopsies from Per1/2 mutant and wild-type (WT) mice were investigated by electron microscopy, immunohistochemistry, and bromodeoxyuridine pulse-chase experiments. TNF-α...
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