Article
Period 2 mutation accelerates ApcMin/+ tumorigenesis.
Molecular cancer research : MCR - 1 Nov 2008
Wood Patricia A, Yang Xiaoming, Taber Andrew, Oh Eun-Young, Ansell Christine, Ayers Stacy E, Al-Assaad Ziad, Carnevale Kevin, Berger Franklin G, Peña Maria Marjorette O, Hrushesky William J M
Abstract excerpt
Colorectal cancer risk is increased in shift workers with presumed circadian disruption. Intestinal epithelial cell proliferation is gated throughout each day by the circadian clock. Period 2 (Per2) is a key circadian clock gene. Per2 mutant (Per2(m/m)) mice show an increase in lymphomas and deregulated expression of cyclin D and c-Myc genes that are key to proliferation control. We asked whether Per2 clock gene...
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