Article

Circadian time-dependent effects of experimental colitis on theophylline disposition and toxicity

2023-11-16

Abstract excerpt

<h4>Background: </h4> and purpose: The impact of inflammatory bowel disease (IBD) on drug disposition is a critical concern, yet whether this impact is circadian time-dependent remains unexplored. We aim to discern the temporal effects of colitis on drug disposition and toxicity. Experimental Approach: The RNA-sequencing was used to screen colitis-affecting genes. The liver microsomal incubation and the pharmacoki...

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Literature Corpus work: b551b6f3-b77f-529e-a4c9-3e2e867aa616
DOI: 10.22541/au.170011989.91586392/v1

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