Article
Presence of the minor EGFR T790M mutation is associated with drug-sensitive EGFR mutations in lung adenocarcinoma patients.
Oncology reports - 1 Jul 2014
Hashida Shinsuke, Soh Junichi, Toyooka Shinichi, Tanaka Tomoaki, Furukawa Masashi, Shien Kazuhiko, Yamamoto Hiromasa, Asano Hiroaki, Tsukuda Kazunori, Hagiwara Koichi, Miyoshi Shinichiro
Abstract excerpt
The T790M mutation in the epidermal growth factor receptor (EGFR) gene is known to be associated with the acquired resistance of lung adenocarcinoma patients to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). The minor T790M mutant allele is occasionally detected in EGFR-TKI-naive tumor samples, yet findings concerning the clinical impact of the minor T790M mutation vary among previous studies. In the present study,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.