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Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer.

Cancer research - 15 Aug 2006

Inukai Michio, Toyooka Shinichi, Ito Sachio, Asano Hiroaki, Ichihara Shuji, Soh Junichi, Suehisa Hiroshi, Ouchida Mamoru, Aoe Keisuke, Aoe Motoi, Kiura Katsuyuki, Shimizu Nobuyoshi, Date Hiroshi

Abstract excerpt

The threonine-to-methionine substitution at amino acid position 790 (T790M) of the epidermal growth factor receptor (EGFR) gene has been reported in progressing lesions after gefitinib treatment in non-small cell lung cancer (NSCLC) that causes sensitive tumors to become resistant to gefitinib. Alternatively, the EGFR T790M mutation might be present in small fractions of tumor cells before drug treatment, and the...

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PMID: 16912157
DOI: 10.1158/0008-5472.CAN-06-1951

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EGFR

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