Article
Detection of EGFR mutations in patients with non-small cell lung cancer by high resolution melting. Comparison with other methods.
Clinical chemistry and laboratory medicine - 26 Oct 2017
Martínez-Carretero Carlos, Pascual Fernando Iguaz, Rus Antonio, Bernardo Ivan
Abstract excerpt
BACKGROUND: The discovery of mutations in the epidermal growth factor receptor gene (EGFR) related to the clinical response to tyrosine kinase inhibitors, has transformed the management of non-small cell lung cancer (NSCLC). Several methods have been developed for determination of mutations in EGFR, with different sensitivity and potential ability to detect a different number of mutations. METHODS: We developed a...
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