Article
The "COLD-PCR approach" for early and cost-effective detection of tyrosine kinase inhibitor resistance mutations in EGFR-positive non-small cell lung cancer.
Applied immunohistochemistry & molecular morphology : AIMM - 1 Jan 2014
Mairinger Fabian D, Vollbrecht Claudia, Streubel Anna, Roth Andreas, Landt Olfert, Walter Henry F R, Kollmeier Jens, Mairinger Thomas
Abstract excerpt
BACKGROUND: Activating epidermal growth factor receptor (EGFR) gene mutations can be successfully treated by EGFR tyrosine kinase inhibitors (EGFR-TKIs), but nearly 50% of all patients' exhibit progression of the disease until treatment because of T790M mutations. It is proposed that this is mostly caused by therapy-resistant tumor clones harboring a T790M mutation. Until now no cost-effective routine-diagnostic...
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