Article
Epidermal growth factor receptor mutation detection using high-resolution melting analysis predicts outcomes in patients with advanced non small cell lung cancer treated with gefitinib.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Sept 2007
Takano Toshimi, Ohe Yuichiro, Tsuta Koji, Fukui Tomoya, Sakamoto Hiromi, Yoshida Teruhiko, Tateishi Ukihide, Nokihara Hiroshi, Yamamoto Noboru, Sekine Ikuo, Kunitoh Hideo, Matsuno Yoshihiro, Furuta Koh, Tamura Tomohide
Abstract excerpt
PURPOSE: Epidermal growth factor receptor (EGFR) mutations, especially deletional mutations in exon 19 (DEL) and L858R, predict gefitinib sensitivity in patients with non-small cell lung cancer (NSCLC). In this study, we validated EGFR mutation detection using high-resolution melting analysis (HR...
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