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Article

Mechanistic details for anthraniloyl transfer in PqsD: the initial step in HHQ biosynthesis.

Journal of molecular modeling - 1 Jun 2014

Hutter Michael C, Brengel Christian, Negri Matthias, Henn Claudia, Zimmer Christina, Hartmann Rolf W, Empting Martin, Steinbach Anke

Abstract excerpt

PqsD mediates the conversion of anthraniloyl-coenzyme A (ACoA) to 2-heptyl-4-hydroxyquinoline (HHQ), a precursor of the Pseudomonas quinolone signal (PQS) molecule. Due to the role of the quinolone signaling pathway of Pseudomonas aeruginosa in the expression of several virulence factors and biofilm formation, PqsD is a potential target for controlling this nosocomial pathogen, which exhibits a low susceptibility...

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Identifiers

PMID: 24842325
DOI: 10.1007/s00894-014-2255-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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