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Article

Kinetic and structural characterisation of the ubiquinol-binding site and oxygen reduction by the trypanosomal alternative oxidase.

Biochimica et biophysica acta. Bioenergetics - 1 Oct 2020

Young Luke, Rosell-Hidalgo Alicia, Inaoka Daniel Ken, Xu Fei, Albury Mary, May Benjamin, Kita Kiyoshi, Moore Anthony L

Abstract excerpt

The alternative oxidase (AOX) is a monotopic di‑iron carboxylate protein which acts as a terminal respiratory chain oxidase in a variety of plants, fungi and protists. Of particular importance is the finding that both emerging infectious diseases caused by human and plant fungal pathogens, the majority of which are multi-drug resistant, appear to be dependent upon AOX activity for survival. Since AOX is absent in...

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PMID: 32565080
DOI: 10.1016/j.bbabio.2020.148247

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