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Interaction of N-3-oxododecanoyl homoserine lactone with transcriptional regulator LasR of Pseudomonas aeruginosa: Insights from molecular docking and dynamics simulations

2019-03-22

Abstract excerpt

<h4>Background: </h4> In 2017, the World Health Organization announced a list of the most dangerous superbugs. Among them is Pseudomonas aeruginosa , an opportunistic human pathogen with high levels of resistance to antibiotics that is listed as one of the ‘ESKAPE’ pathogens, which are the leading cause of nosocomial infections. A major issue is that it mostly affects vulnerable patients such as those suffering f...

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Literature Corpus work
5cbe11d0-9f34-561d-a47c-5b73e191624b
DOI
10.12688/f1000research.18435.1
Open publication

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