Article
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction.
The Journal of biological chemistry - 17 Mar 2006
Horsefield Rob, Yankovskaya Victoria, Sexton Graham, Whittingham William, Shiomi Kazuro, Omura Satoshi, Byrne Bernadette, Cecchini Gary, Iwata So
Abstract excerpt
The transfer of electrons and protons between membrane-bound respiratory complexes is facilitated by lipid-soluble redox-active quinone molecules (Q). This work presents a structural analysis of the quinone-binding site (Q-site) identified in succinate:ubiquinone oxidoreductase (SQR) from Escherichia coli. SQR, often referred to as Complex II or succinate dehydrogenase, is a functional member of the Krebs cycle...
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