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Pyrroloquinoline quinone biogenesis: characterization of PqqC and its H84N and H84A active site variants.

Biochemistry - 19 Jun 2007

Magnusson Olafur Th, RoseFigura Jordan M, Toyama Hirohide, Schwarzenbacher Robert, Klinman Judith P

Abstract excerpt

Pyrroloquinoline quinone [4,5-dihydro-4,5-dioxo-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid (PQQ)] is a bacterial vitamin that serves as a cofactor in numerous alcohol dehydrogenases. Its biosynthesis in Klebsiella pneumoniae is facilitated by six genes, pqqABCDEF, and proceeds by an unknown pathway. The protein encoded by pqqC catalyzes the final step of PQQ formation, which involves a ring closure and...

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PMID: 17523676
DOI: 10.1021/bi700162n

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pyrroloquinoline quinone biogenesis: characterization of PqqC and its H84N and H84A active site variants.PMID 17523676Read ↗

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