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Human Tissue Kallikreins: Physiologic Roles and Applications in Cancer

1 May 2004

Abstract excerpt

Tissue kallikreins are members of the S1 family (clan SA) of trypsin-like serine proteases and are present in at least six mammalian orders. In humans, tissue kallikreins (hK) are encoded by 15 structurally similar, steroid hormone-regulated genes (KLK) that colocalize to chromosome 19q13.4, representing the largest cluster of contiguous protease genes in the entire genome. hKs are widely expressed in diverse...

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Identifiers

PMID: 15192120
DOI: 10.1158/1541-7786.257.2.5

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Source receipt: pubmed, retrieved 7 Sept 2026.

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