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Article

Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.

The Journal of biological chemistry - 16 Aug 2013

Németh Balázs Csaba, Wartmann Thomas, Halangk Walter, Sahin-Tóth Miklós

Abstract excerpt

Chymotrypsin C (CTRC) is a proteolytic regulator of trypsinogen autoactivation in humans. CTRC cleavage of the trypsinogen activation peptide stimulates autoactivation, whereas cleavage of the calcium binding loop promotes trypsinogen degradation. Trypsinogen mutations that alter these regulatory cleavages lead to increased intrapancreatic trypsinogen activation and cause hereditary pancreatitis. The aim of this...

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Source

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Identifiers

PMID: 23814066
DOI: 10.1074/jbc.M113.478800
PMCID: PMC3745349

Genes

CTRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autoactivation of mouse trypsinogens is regulated by chymotrypsin C via cleavage of the autolysis loop.PMID 23814066Read ↗

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