Article
Positive feedback within a kinase signaling complex functions as a switch mechanism for NF-κB activation.
Science (New York, N.Y.) - 16 May 2014
Shinohara Hisaaki, Behar Marcelo, Inoue Kentaro, Hiroshima Michio, Yasuda Tomoharu, Nagashima Takeshi, Kimura Shuhei, Sanjo Hideki, Maeda Shiori, Yumoto Noriko, Ki Sewon, Akira Shizuo, Sako Yasushi, Hoffmann Alexander, Kurosaki Tomohiro, Okada-Hatakeyama Mariko
Abstract excerpt
A switchlike response in nuclear factor-κB (NF-κB) activity implies the existence of a threshold in the NF-κB signaling module. We show that the CARD-containing MAGUK protein 1 (CARMA1, also called CARD11)-TAK1 (MAP3K7)-inhibitor of NF-κB (IκB) kinase-β (IKKβ) module is a switch mechanism for NF-κB activation in B cell receptor (BCR) signaling. Experimental and mathematical modeling analyses showed that IKK...
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