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Article

The MAGUK family protein CARD11 is essential for lymphocyte activation.

Immunity - 1 Jun 2003

Hara Hiromitsu, Wada Teiji, Bakal Chris, Kozieradzki Ivona, Suzuki Shinobu, Suzuki Nobutaka, Nghiem Mai, Griffiths Emily K, Krawczyk Connie, Bauer Birgit, D'Acquisto Fulvio, Ghosh Sankar, Yeh Wen Chen, Baier Gottfried, Rottapel Robert, Penninger Josef M

Abstract excerpt

Members of the MAGUK family proteins cluster receptors and intracellular signaling molecules at the neuronal synapse. We report that genetic inactivation of the MAGUK family protein CARD11/Carma1/Bimp3 results in a complete block in T and B cell immunity. CARD11 is essential for antigen receptor- and PKC-mediated proliferation and cytokine production in T and B cells due to a selective defect in JNK and NFkappaB...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to JNK Mitogen-Activated Protein Kinases

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Share to Receptors, Antigen

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Source

Identifiers

PMID: 12818158
DOI: 10.1016/s1074-7613(03)00148-1

Genes

CARD11
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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