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Article

3β,5α,6β-Cholestanetriol and 25-hydroxycholesterol accumulate in ATP-binding cassette transporter G1 (ABCG1)-deficiency.

Atherosclerosis - 1 Jul 2014

Engel Thomas, Fobker Manfred, Buchmann Jana, Kannenberg Frank, Rust Stephan, Nofer Jerzy-Roch, Schürmann Annette, Seedorf Udo

Abstract excerpt

OBJECTIVE: Oxysterols are oxidized derivatives of sterols that have cytotoxic effects and are potent regulators of diverse cellular functions. Efficient oxysterol removal by the sub-family G member 1 of the ATP-binding cassette transporters (ABCG1) is essential for cell survival and control of cellular processes. However, the specific role of ABCG1 in the transport of various oxysterol species has been not...

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Source

Identifiers

PMID: 24833118
DOI: 10.1016/j.atherosclerosis.2014.04.023

Genes

ABCG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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