Article
Tumor necrosis factor analogs: identification of functional domains.
Anticancer research - 1 Jan 2000
Sidhu R S, Bollon A P
Abstract excerpt
Truncated tumor necrosis factor analogs were produced by making in vitro deletions of the coding sequence of the human TNF gene. One of these analogs, TNF-desA7, lacked seven amino terminal residues of the mature TNF protein and the other two analogs, TNF-desC7 and TNF-desC2, had deletions of sev...
Topics
- Amino Acid Sequence
- Antibodies, Monoclonal
- Base Sequence
- Cloning, Molecular
- DNA
- Epitopes
- Genes
- Humans
- Immunoblotting
- Immunoenzyme Techniques
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Plasmids
- Recombinant Proteins
- Sequence Homology, Nucleic Acid
- Tumor Necrosis Factor-alpha