Tumor necrosis factor analogs: identification of functional domains.

Abstract excerpt

Truncated tumor necrosis factor analogs were produced by making in vitro deletions of the coding sequence of the human TNF gene. One of these analogs, TNF-desA7, lacked seven amino terminal residues of the mature TNF protein and the other two analogs, TNF-desC7 and TNF-desC2, had deletions of seven and two carboxy terminal amino acids, respectively. While the deletion of the first seven amino acid residues did...

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