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Article

Computational design of variant TNF molecules: a novel methodology for inhibition of proinflammatory cascades.

Science's STKE : signal transduction knowledge environment - 11 Nov 2003

Abraham Edward

Abstract excerpt

Site-directed mutagenesis of tumor necrosis factor (TNF) based on prediction of the interaction of specific residues with TNF receptors generated dominant-negative constructs, in which single- or double-amino acid changes result in decreased receptor binding and cellular activation. These dominant-negatives not only provide a novel manner to block the proinflammatory effects of TNF, but also can be used as a tool...

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Identifiers

PMID: 14612594
DOI: 10.1126/stke.2003.208.pe51

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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