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A Receptor for Tumor Necrosis Factor Defines an Unusual Family of Cellular and Viral Proteins

25 May 1990

Abstract excerpt

Tumor necrosis factor alpha and beta (TNF-alpha and TNF-beta) bind surface receptors on a variety of cell types to mediate a wide range of immunological responses, inflammatory reactions, and anti-tumor effects. A cDNA clone encoding an integral membrane protein of 461 amino acids was isolated from a human lung fibroblast library by direct expression screening with radiolabeled TNF-alpha. The encoded receptor was...

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PMID: 2160731
DOI: 10.1126/science.2160731

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