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Article

Novel protein engineering strategy for creating highly receptor-selective mutant TNFs.

Biochemical and biophysical research communications - 30 Oct 2009

Nomura Tetsuya, Abe Yasuhiro, Kamada Haruhiko, Inoue Masaki, Kawara Tomoyuki, Arita Shuhei, Furuya Takeshi, Yoshioka Yasuo, Shibata Hiroko, Kayamuro Hiroyuki, Yamashita Takuya, Nagano Kazuya, Yoshikawa Tomoaki, Mukai Yohei, Nakagawa Shinsaku, Taniai Madoka, Ohta Tsunetaka, Tsunoda Shin-ichi, Tsutsumi Yasuo

Abstract excerpt

Tumor necrosis factor (TNF) plays important roles in host defense and in preventing tumor formation by acting via its receptors, TNFR1 and TNFR2, functions of which are less understood. To this end, we have been isolating TNF receptor-selective mutants using phage display technique. However, gene...

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Source

Identifiers

PMID: 19682974
DOI: 10.1016/j.bbrc.2009.08.052

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19682974-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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