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Article

Epigenetic changes in solid and hematopoietic tumors.

Seminars in oncology - 1 Oct 2005

Toyota Minoru, Issa Jean-Pierre J

Abstract excerpt

There are three connected molecular mechanisms of epigenetic cellular memory in mammalian cells: DNA methylation, histone modifications, and RNA interference. The first two have now been firmly linked to neoplastic transformation. Hypermethylation of CpG-rich promoters triggers local histone code modifications resulting in a cellular camouflage mechanism that sequesters gene promoters away from transcription...

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Identifiers

PMID: 16210093
DOI: 10.1053/j.seminoncol.2005.07.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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