Article
Low homozygous/high heterozygous deletion status by p16 FISH correlates with a better prognostic group than high homozygous deletion status in malignant pleural mesothelioma.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2016
Hamasaki Makoto, Matsumoto Shinji, Abe Sousei, Hamatake Daisuke, Kamei Toshiaki, Hiroshima Kenzo, Kawahara Kunimitsu, Sato Ayuko, Tsujimura Tohru, Nakatani Yukio, Yoshida Yasuhiro, Iwasaki Akinori, Nabeshima Kazuki
Abstract excerpt
OBJECTIVES: Homozygous deletion (homo-d) of the p16 (CDKN2A) gene, as determined by fluorescence in situ hybridization (FISH), helps differentiate malignant pleural mesothelioma (MPM) from reactive mesothelial hyperplasia (RMH). Heterozygous deletion (hetero-d) has also been identified variably in p16 FISH. This study aimed to investigate the significance of homo-d and hetero-d of p16 in the diagnosis and...
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