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ABERRANT DNA METHYLATION AS A CANCER-INDUCING MECHANISM

28 Jan 2005

Abstract excerpt

Aberrant DNA methylation is the most common molecular lesion of the cancer cell. Neither gene mutations (nucleotide changes, deletions, recombinations) nor cytogenetic abnormalities are as common in human tumors as DNA methylation alterations. The most studied change of DNA methylation in neoplasms is the silencing of tumor suppressor genes by CpG island promoter hypermethylation, which targets genes such as...

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PMID: 15822191
DOI: 10.1146/annurev.pharmtox.45.120403.095832

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