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Article

The linker histone H1.0 generates epigenetic and functional intratumor heterogeneity

29 Sept 2016

Abstract excerpt

INTRODUCTION Cancer arises from clonal expansion of a single cell. Yet, most human cancers are characterized by extensive intratumor heterogeneity and comprise various subpopulations of cells with distinct phenotypes and biological properties. Intratumor heterogeneity poses major challenges in understanding cancers, managing patients, and designing effective treatment strategies. Functional heterogeneity within...

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PMID: 27708074
DOI: 10.1126/science.aaf1644

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