Article
A YY1-dependent increase in aerobic metabolism is indispensable for intestinal organogenesis.
Development (Cambridge, England) - 15 Oct 2016
Kumar Namit, Srivillibhuthur Manasa, Joshi Shilpy, Walton Katherine D, Zhou Anbo, Faller William J, Perekatt Ansu O, Sansom Owen J, Gumucio Deborah L, Xing Jinchuan, Bonder Edward M, Gao Nan, White Eileen, Verzi Michael P
Abstract excerpt
During late gestation, villi extend into the intestinal lumen to dramatically increase the surface area of the intestinal epithelium, preparing the gut for the neonatal diet. Incomplete development of the intestine is the most common gastrointestinal complication in neonates, but the causes are unclear. We provide evidence in mice that Yin Yang 1 (Yy1) is crucial for intestinal villus development. YY1 loss in the...
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