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Article

GADD45a promoter regulation by a functional genetic variant associated with acute lung injury.

PloS one - 1 Jan 2014

Mitra Sumegha, Wade Michael S, Sun Xiaoguang, Moldobaeva Nurgul, Flores Carlos, Ma Shwu-Fan, Zhang Wei, Garcia Joe G N, Jacobson Jeffrey R

Abstract excerpt

RATIONALE: Growth arrest DNA damage inducible alpha (GADD45a) is a stress-induced gene we have shown to participate in the pathophysiology of ventilator-induced lung injury (VILI) via regulation of mechanical stress-induced Akt ubiquitination and phosphorylation. The regulation of GADD45a expression by mechanical stress and its relationship with acute lung injury (ALI) susceptibility and severity, however,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24940746
DOI: 10.1371/journal.pone.0100169
PMCID: PMC4062486

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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