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Reversing Mechanoinductive DSP Expression by CRISPR/dCas9–mediated Epigenome Editing

20 Jun 2018

Abstract excerpt

RATIONALE: DSP (desmoplakin), the most abundant component of desmosomes, which maintain the mechanical integrity of epithelium, is a genome-wide association study-identified genetic risk locus in human idiopathic pulmonary fibrosis (IPF). Subjects with IPF express a significantly higher level of DSP than control subjects. OBJECTIVES: Determine potential mechanisms by which DSP is regulated in lung fibrosis....

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PMID: 29924937
DOI: 10.1164/rccm.201711-2242oc

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