Article
eNAMPT/TLR4 signaling drives PAH cellular phenotypic switching and lung vascular remodeling.
Cell communication and signaling : CCS - 29 Oct 2025
Ahmed Mohamed, Kee Shaira L, Zaghloul Nahla, Casanova Nancy G, Rodriguez Marisela, Kempf Carrie L, Camp Sara M, Song Jin H, Sammani Saad, Gupta Akash, Bryant Andrew J, Ooi Aikseng, Desai Ankit A, Makino Ayako, Yuan Jason X-J, Benos Panayiotis V, Dai Zhiyu, Garcia Joe G N
Abstract excerpt
BACKGROUND: The attenuation of cellular phenotypic switchingdriving PAH vascular remodeling remains an unmet therapeutic need. As eNAMPT (nicotinamide phosphoribosyltransferase)/TLR4 signaling significantly contributes to PH pathobiology, an eNAMPT-neutralizing ALT-100 mAb was utilized to rescue monocrotaline (MCT) and hypoxia/Sugen (Hy/Su) preclinical PH rat models and to evaluate eNAMPT/TLR4 involvement in...
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