Article
Genome-wide identification of interferon-sensitive mutations enables influenza vaccine design.
Science (New York, N.Y.) - 19 Jan 2018
Du Yushen, Xin Li, Shi Yuan, Zhang Tian-Hao, Wu Nicholas C, Dai Lei, Gong Danyang, Brar Gurpreet, Shu Sara, Luo Jiadi, Reiley William, Tseng Yen-Wen, Bai Hongyan, Wu Ting-Ting, Wang Jieru, Shu Yuelong, Sun Ren
Abstract excerpt
In conventional attenuated viral vaccines, immunogenicity is often suboptimal. Here we present a systematic approach for vaccine development that eliminates interferon (IFN)-modulating functions genome-wide while maintaining virus replication fitness. We applied a quantitative high-throughput genomics system to influenza A virus that simultaneously measured the replication fitness and IFN sensitivity of mutations...
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