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Article

Interleukin-6 induces neuroendocrine differentiation (NED) through suppression of RE-1 silencing transcription factor (REST).

The Prostate - 1 Aug 2014

Zhu Yezi, Liu Chengfei, Cui Yuanyuan, Nadiminty Nagalakshmi, Lou Wei, Gao Allen C

Abstract excerpt

BACKGROUND: Paracrine interleukin-6 (IL-6) can mediate neuroendocrine (NE) features, including the acquisition of a neurite-like phenotype and growth arrest in prostate cancer cells. However, little is known about the mechanisms underlying neuroendocrine differentiation induced by IL-6. METHODS: Immunoblotting was performed to determine the status of RE1-silencing transcription factor (REST) and of neuroendocrine...

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Source

Identifiers

PMID: 24819501
DOI: 10.1002/pros.22819

Genes

REST

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Interleukin-6 induces neuroendocrine differentiation (NED) through suppression of RE-1 silencing transcription factor (REST).PMID 24819501Read ↗

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STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cellsSemantic proximity Read ↗

REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancerSemantic proximity Read ↗

Interleukin-6 inhibits the growth of prostate cancer xenografts in mice by the process of neuroendocrine differentiation.Semantic proximity Read ↗

IB1/JIP-1 controls JNK activation and increased during prostatic LNCaP cells neuroendocrine differentiation.Semantic proximity Read ↗

The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype.Semantic proximity Read ↗

Androgen deprivation induces neuroendocrine phenotypes in prostate cancer cells through CREB1/EZH2-mediated downregulation of RESTSemantic proximity Read ↗

C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.Semantic proximity Read ↗

NRSF/REST levels are decreased in cholangiocellular carcinoma but not hepatocellular carcinoma compared with normal liver tissues: A tissue microarray studySemantic proximity Read ↗

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