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Article

STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cells

15 Feb 2000

Abstract excerpt

BACKGROUND: In the human prostate cancer cell line LNCaP, interleukin (IL)-6 has been shown to regulate both growth and neuroendocrine (NE) differentiation. We recently observed that IL-6 mediated growth arrest in LNCaP by activating STAT 3. Since differentiation and growth arrest are often associated processes, we investigated whether STAT3 also mediated NE differentiation in this prostate cancer cell line....

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PMID: 10639189
DOI: 10.1002/(sici)1097-0045(20000215)42:3<186::aid-pros4>3.0.co;2-e

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STAT3 mediates IL-6-induced neuroendocrine differentiation in prostate cancer cellsPMID 10639189Read ↗

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