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Article

The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype.

Journal of neurochemistry - 1 Sept 2006

Bruce Alexander W, Krejcí Alena, Ooi Lezanne, Deuchars James, Wood Ian C, Dolezal Vladimír, Buckley Noel J

Abstract excerpt

Release of distinct cellular cargoes in response to specific stimuli is a process fundamental to all higher eukaryotes and controlled by the regulated secretory pathway (RSP). However, the mechanism by which genes involved in the RSP are selectively expressed, leading to the establishment and app...

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Source

Identifiers

PMID: 16945103
DOI: 10.1111/j.1471-4159.2006.04010.x

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16945103-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The transcriptional repressor REST is a critical regulator of the neurosecretory phenotype.PMID 16945103Read ↗

A role for the transcriptional repressor REST in maintaining the phenotype of neurosecretory-deficient PC12 cells.Semantic proximity Read ↗

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RNA Splicing Factors SRRM3 and SRRM4 Distinguish Molecular Phenotypes of Castration-Resistant Neuroendocrine Prostate CancerSemantic proximity Read ↗

The transcriptional repressor REST determines the cell-specific expression of the human MAPK8IP1 gene encoding IB1 (JIP-1).Semantic proximity Read ↗

C-terminal domain small phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.Semantic proximity Read ↗

Restoration of early postnatal synaptic dysregulation rescues polyglutamine-mediated motor neuron degeneration in miceSemantic proximity Read ↗

Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b.Semantic proximity Read ↗

Neurosecretion competence, an independently regulated trait of the neurosecretory cell phenotype.Semantic proximity Read ↗

REST mediates androgen receptor actions on gene repression and predicts early recurrence of prostate cancerSemantic proximity Read ↗

Interleukin-6 induces neuroendocrine differentiation (NED) through suppression of RE-1 silencing transcription factor (REST).Semantic proximity Read ↗

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